1 in 5 women experience conception challenges
Oocytes (egg cells) are known to contain the greatest number of mitochondria in any cell by one or two orders of magnitude because of the intense energy demands of their development and role in the reproductive process5
References: 1. CDC. Infertility FAQs. https://www.cdc.gov/reproductivehealth/infertility/index.htm. Accessed Aug 21, 2023. 2. Pasch LA, Holley SR, Bleil ME, et al. Addressing the needs of fertility treatment patients and their partners: are they informed of and do they receive mental health services? Fertil Steril. 2016;106(1):209-215. 3. Deka PK, Sarma S. Psychological aspects of infertility. BJMP. 2010;3(3):a336. 4. van der Reest J, Cecchino GN, Haigis MC, Kordowitzki P. Mitochondria: their relevance during oocyte ageing. Ageing Res Rev. 2021;70:101378. 5. Bentov Y, Casper RF. The aging oocyte—can mitochondrial function be improved? Fertil Steril. 2013;99(1):18-22. 6. Agarwal A, Aponte-Mellado A, Premkumar BJ, et al. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49. 7. Zhu Z, Xu W, Liu L. Ovarian aging: mechanisms and intervention strategies. Med Rev. 2022;2(6):590-610. 8. Adhikari D, Lee I, Yuen WS, Carroll J. Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility. Biol Reprod. 2022;106(2):366-377. 9. Bartmann AK, Romão GS, da Silveira Ramos E, Ferriani RA. Why do older women have poor implantation rates? A possible role of the mitochondria. J Assist Reprod Genet. 2004;21(3):79-83.
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