Mitochondrial Health - Kaneka Preconception

1 in 5 women experience conception challenges

Not an actual patient.

According to the CDC, among married women up to age 49 with no prior births, about 19% struggle with conception1

Among couples with issues trying to conceive, women experience higher levels of distress than men2-3 

Mitochondrial energy production is crucial for oocytes (egg cells)4

Oocytes (egg cells) are known to contain the greatest number of mitochondria in any cell by one or two orders of magnitude because of the intense energy demands of their development and role in the reproductive process5

Protecting mitochondria from free radical damage is vital for reproductive health4-9

  • Aging mitochondria exhibit leakage of reactive oxygen species (ROS)
    • Excess ROS results in oxidative stress, which can lead to mitochondrial damage
    • Older reproductive cells have more cumulative damage, less ability to neutralize ROS and decreased efficiency of internal repair mechanisms
  • The result is increased ROS production, and decreased production of new mitochondria, which affects energy production, growth, and the overall reproductive capability of oocytes*



References: 1. CDC. Infertility FAQs. Accessed Aug 21, 2023. 2. Pasch LA, Holley SR, Bleil ME, et al. Addressing the needs of fertility treatment patients and their partners: are they informed of and do they receive mental health services? Fertil Steril. 2016;106(1):209-215. 3. Deka PK, Sarma S. Psychological aspects of infertility. BJMP. 2010;3(3):a336. 4. van der Reest J, Cecchino GN, Haigis MC, Kordowitzki P. Mitochondria: their relevance during oocyte ageing. Ageing Res Rev. 2021;70:101378. 5. Bentov Y, Casper RF. The aging oocyte—can mitochondrial function be improved? Fertil Steril. 2013;99(1):18-22. 6. Agarwal A, Aponte-Mellado A, Premkumar BJ, et al. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49. 7. Zhu Z, Xu W, Liu L. Ovarian aging: mechanisms and intervention strategies. Med Rev. 2022;2(6):590-610. 8. Adhikari D, Lee I, Yuen WS, Carroll J. Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility. Biol Reprod. 2022;106(2):366-377. 9. Bartmann AK, Romão GS, da Silveira Ramos E, Ferriani RA. Why do older women have poor implantation rates? A possible role of the mitochondria. J Assist Reprod Genet. 2004;21(3):79-83.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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